Acetyl chloride → HCID 67748007, compound

Participants

Reaction Conditions

Reaction Steps

A solution was 50 mg of the resultant compound of Example 185 and 20 mg of 10% Pd/C was stirred vigorously under a hydrogen atmosphere. After 30 minutes, the catalyst was filtered off and the filtrate concentrated to give a colorless oil, which was dissolved in 2 ml of CH2Cl2. The solution was cooled to 0° C., 0.03 ml of triethylamine and 0.01 ml of acetyl chloride was added. After 2 hrs, the solution was concentrated and the crude product purified by silica gel column chromatography (5% MeOH/CH2Cl2) to give 16 mg of the desired compound. Mass spectrum: (M+H)+ =565.

Provenance & Evidence