2-(Boc-valinyl-amino)-4-(Cbz-valinyl-amino)-1,5-diphenyl-3-hydroxypentane → 4-(Cbz-valinyl-amino)-2-(valinyl-amino)-1,5-diphenyl-3-hydroxypentane

Participants

Reaction Steps

Using the procedure of Example 12 with the resultant compound of Example 239 provided a crude hydrochloride salt which was partitioned between chloroform and aqueous NaHCO3, dried over Na2SO4, and concentrated. Chromatography of the residue on silica gel using 3% methanol in chloroform provided in 89% yield the desired compound (Rf 0.5, 10% methanol in chloroform) as a white solid, m.p. 126°-127° C. Mass spectrum: (M+H)+ =603.

Provenance & Evidence