Sodium Hydroxide → (2,4,5-Tribromo-imidazol-1-yl)-acetic acid

HRID 84769Notes

Reaction equation

HRID 84769 reaction equation
[OH-].[Na+].C[O:4][C:5](=[O:15])[CH2:6][N:7]1[C:11]([Br:12])=[C:10]([Br:13])[N:9]=[C:8]1[Br:14]>CO>[Br:14][C:8]1[N:7]([CH2:6][C:5]([OH:15])=[O:4])[C:11]([Br:12])=[C:10]([Br:13])[N:9]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86686619HCID 86686619, compound

Product 1

HCID 86686618(2,4,5-Tribromo-imidazol-1-yl)-acetic acidYield 98.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

18 mL 4 mol/L aqueous sodiumhydroxide solution was added to 18.1 g (2,4,5-tribromo-imidazol-1-yl)-acetic acid methyl ester in 200 mL MeOH. The reaction was stirred 1 h at RT and evaporated. Water was added to the residue and the resulting mixture acidified with 1 mol/L aqueous HCL solution. The precipitate was filtered and dried to give 17.2 g desired product.

Workup

  1. customevaporated
  2. additionWater was added to the residue
  3. filtrationThe precipitate was filtered
  4. customdried

Sources & evidence

ORD record
ord-fa1fb0d1751040cc96f74e050d108a91
Source dataset
uspto-grants-2014_09
Patent number
US08846948B2

Reaction notes

Loading…