HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorobenzamide → 1-(2-Chlorobenzoyl)-3-(5-trifluoromethyl-2-pyrazinyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorobenzamide | HCID 69111 | — |
| Reactant | 2-Isocyanatopyrazine | HCID 18987644 | — |
| Reactant | Pyrazine, 2-isocyanato-5-(trifluoromethyl)- | HCID 20567021 | — |
| Product | 1-(2-Chlorobenzoyl)-3-(5-trifluoromethyl-2-pyrazinyl)urea | HCID 13341081 | — |
Reaction Steps
A compound of formula I may also be prepared by allowing a 2-substituted benzamide to react with a 2-pyrazinylisocyanate utilizing the appropriate solvents, times of reaction and general reaction conditions hereinabove described. For example, 2-chlorobenzamide is allowed to react with 5-trifluoromethylpyrazin-2-ylisocyanate to yield 1-(2-chlorobenzoyl)-3-(5-trifluoromethyl-2-pyrazinyl)urea, having a melting point of about 219°-220° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04293552 |
| Source dataset | uspto-grants-1981_10 |
| ORD ID | ord-201e548ca6654fdda4946ea34b17dce2 |
| Source note | uspto-grants-1981_10 |