2-Chlorobenzoyl isocyanate → 1-(2-Chlorobenzoyl)-3-[5-(4-chlorophenyl)-2-pyrazinyl]urea

HRID 847715Notes

Reaction equation

HRID 847715 reaction equation
[Cl:1][C:2]1[CH:29]=[CH:28][CH:27]=[CH:26][C:3]=1[C:4]([NH:6][C:7]([NH:9][C:10]1[CH:15]=[N:14][C:13]([C:16]2[CH:21]=[CH:20][C:19](C(F)(F)F)=[CH:18][CH:17]=2)=[CH:12][N:11]=1)=[O:8])=[O:5].NC1C=NC(C2C=CC(C(F)(F)F)=CC=2)=CN=1.[Cl:47]C1C=CC=CC=1C(N=C=O)=O>>[Cl:1][C:2]1[CH:29]=[CH:28][CH:27]=[CH:26][C:3]=1[C:4]([NH:6][C:7]([NH:9][C:10]1[CH:15]=[N:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([Cl:47])=[CH:18][CH:17]=2)=[CH:12][N:11]=1)=[O:8])=[O:5]

Participants

4

Reactant 3

HCID 99423112-Chlorobenzoyl isocyanateHCID 133411061-(2-Chlorobenzoyl)-3-[5-(alpha,alpha,alpha-trifluoro-p-tolyl)-2-pyrazinyl]ureaHCID 205670592-Amino-5-(4-trifluoromethylphenyl)pyrazine

Product 1

HCID 133410931-(2-Chlorobenzoyl)-3-[5-(4-chlorophenyl)-2-pyrazinyl]urea

Procedure

2M. 1-(2-Chlorobenzoyl)-3-[5-(α,α,α-trifluoro-p-tolyl)-2-pyrazinyl]urea, having a melting point of about 213°-215° C., and weighing 0.6 g., from 0.6 g. of 2-amino-5-(α,α,α-trifluoro-p-tolyl)pyrazine and 0.55 g. of 2-chlorobenzoyl isocyanate.

Sources & evidence

ORD record
ord-d2e2d30f149542bab0c85bb4f3411953
Source dataset
uspto-grants-1981_10
Patent number
US04293552

Reaction notes

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