反应详情

A mixture of thiophene-2-carboxaldehyde (5.6 g; 0.05 mole), 3-n-butylhydantoin (7.8 g; 0.05 mole) and ethanolamine (4.6 g; 0.075 mole) in water/ethanol (50 ml/30 ml) was stirred and boiled under reflux for 4 hours. The mixture was cooled in the refrigerator and the resultant brownish yellow crystals filtered off, washed with water, sucked dry and recrystallised from ethyl acetate (with carbon treatment) to give the title compound (6.4 g; 51%) having m.p. 140° C.

1. temperatureunder reflux for 4 hours
2. temperatureThe mixture was cooled in the refrigerator
3. filtrationthe resultant brownish yellow crystals filtered off
4. washwashed with water
5. customsucked dry
6. customrecrystallised from ethyl acetate (with carbon treatment)