Sodium Formate → HCID 12898570, compound

Participants

Reaction Steps

A mixture of 1 g of 3-[3-(1-piperidinylmethyl)phenoxy]propylamine, 1 g of sodium formate and 3 ml of formic acid was refluxed for 1 hour, and a greater portion of the solvent was distilled off under reduced pressure, and water was added to the residue. The mixture was alkalized with 4% sodium hydroxide solution. The product was extracted with chloroform. The extract was dried over anhydrous magnesium sulfate. The solvent was distilled off, and the residue was separated and purified by thin-layer chromatography (TLC) (developing solvent: chloroform/methanol=9/l) to afford 436 mg of N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]formamide as an oil.

Provenance & Evidence