HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → Roxatidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Glycolic Acid | HCID 757 | — |
| Reactant | 3-(3-(Piperidin-1-ylmethyl)phenoxy)propan-1-amine | HCID 10220561 | — |
| Solvent | Water | HCID 962 | — |
| Product | Roxatidine | HCID 91276 | 94.8% |
Reaction Steps
1.59 g of 3-[3-(1-piperidinylmethyl)phenoxy]propylamine and 536 mg of hydroxyacetic acid were heated at 200° C. for 2 hours. The reaction mixture was cooled, and water was added. The mixture was alkalized with aqueous ammonia, and extracted with chloroform. The extract was dried over anhydrous sodium sulfate, and the solvent was distilled off to afford 1.86 g of N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydroxyacetamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04293557 |
| Source dataset | uspto-grants-1981_10 |
| ORD ID | ord-aefa9d752e97463fb78632850c5f4ee1 |
| Source note | uspto-grants-1981_10 |