Dimethylformamide → HCID 20567167, compound

Participants

Reaction Steps

15 g of 3-(1-piperidinylmethyl)phenol was dissolved in 80 ml of dry dimethylformamide. The solution was gradually added dropwise to a suspension of 3.14 g of 60% sodium hydride in 30 ml of dry dimethylformamide with stirring under ice cooling. After the addition, the mixture was stirred at room temperature for 20 minutes, and 21 g of N-bromopropylphthalimide was added. The mixture was reacted at room temperature for 1 hour, and ice water was added. The mixture was extracted with chloroform, washed with water and dried over anhydrous magnesium sulfate. Distilling off the solvent afforded 28.5 g of N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]phthalamide as an oil.

Provenance & Evidence