Methyl p-toluenesulfonate → N-(2,3-dimethylbenzothiazole-6-sulfonyl)piperidine tosylate

Participants

Reaction Conditions

Reaction Steps

A mixture of Compound 3 (1.0 g, 3.4 mmol) and p-toluenesulfonic acid methyl ester (0.94 g, 5.1 mmol) was heated in a pressure tube at 130° C. for 1 hour. The mixture was allowed to cool to room temperature, and the resulting mass was triturated with acetone (25 ml) until a gray colored solid separated. The solid was collected by centrifugation, washed with acetone and dried under vacuum to yield 1.4 g (86%) of Compound 4 whose structure is given below:

Provenance & Evidence