反应详情

温度

117.5 °C

Chlorosulfonic acid (12.5 ml, 187.8 mmol) was cooled in an ice bath and 2-methylbenzoxazole (5.0 g, 37.5 mmol) was carefully added drop wise over a period of 15 min. The combined mixture was heated at 115-120° C. for 16 hours. After cooling, the mixture was added very slowly to ca. 100 ml ice/water mix. The white solid that separated was collected by filtration, washed with water until washings were neutral and dried to yield 5.2 g (59%) of Compound 8, whose structure is given below:

1. customof 15 min
2. temperatureAfter cooling
3. additionmix
4. customThe white solid that separated
5. filtrationwas collected by filtration
6. washwashed with water until washings
7. customdried