HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Ethoxy-2-methyl-6-(2,2-diethoxycarbonylethenyl)aminopyridine → Ethyl 6-ethoxy-4-hydroxy-7-methyl-1,8-naphthyridine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Ethoxy-2-methyl-6-(2,2-diethoxycarbonylethenyl)aminopyridine | HCID 12875018 | — |
| Solvent | 1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) | HCID 24670 | — |
| Product | Ethyl 6-ethoxy-4-hydroxy-7-methyl-1,8-naphthyridine-3-carboxylate | HCID 178469690 | — |
Reaction Steps
16.1 g of the Compound VI obtained as above was added to 160 ml of boiling Dowtherm (produced by Dow Chemical Co.) and refluxed for 1 hour. After cooling, the precipitated crystals were collected by filtration to obtain 11.8 g of crude crystals which were then recrystallized from dimethylformamide to yield ethyl 6-ethoxy-4-hydroxy-7-methyl-1,8-naphthyridine-3-carboxylate (Compound VII where R2 =R3 =C2H5), m.p. 279°-282° C. (with decomposition).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04293695 |
| Source dataset | uspto-grants-1981_10 |
| ORD ID | ord-06ed29e55c7f4346a522b66aacd0fc10 |
| Source note | uspto-grants-1981_10 |