Selenium Dioxide → HCID 12875021, compound

Participants

Reaction Steps

20.2 g of the Compound VIII obtained as above was heated at 175°-185° C. under a nitrogen stream to melt and 10 g of selenium dioxide was added in several portions. Under a nitrogen stream, the mixture was reacted under the same conditions for 20 minutes. After allowing to cool, chloroform was added to the reaction mixture and the insoluble materials were removed by filtration and the filtrate was concentrated in vacuo. The resulting residue was recrystallized from ethanol to yield 13.2 g of ethyl 1,4-dihydro-6-ethoxy-1-ethyl-7-formyl-4-oxo-1,8-naphthyridine-3-carboxylate having a melting point of 169°-170° C.

Provenance & Evidence