HCID 12788721, compound → HCID 12788722, compound

Participants

Reaction Steps

300 mg of the crude ethyl 3-chloro-5-ethyl-8-oxo-2,3,5,8-tetrahydrofuro[3,2-b]-1,8-naphthyridine-7-carboxylate (Compound XII where R1 =R3 =C2H5) obtained above was dissolved in 30 ml of methanol, which was reduced over 5% palladium black (200 mg) under atmospheric pressure. After reaction, the catalyst was filtered off and the solvent was distilled off under reduced pressure to obtain 240 mg of crude ethyl 5-ethyl-8-oxo-2,3,5,8-tetrahydrofuro[3,2-b]-1,8-naphthyridine-7-carboxylate.

Provenance & Evidence