1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 12875025, compound

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Reaction Steps

To a solution of 3.2 g of ethyl 3-chloro-5-ethyl-8-oxo-2,3,5,8-tetrahydrofuro[3,2-b]-1,8-naphthyridine-7-carboxylate (Compound XII where R1 =R3 =C2H5, X=Cl) dissolved in 50 ml of dimethylformamide, 3.2 g of 1,8-diazabicyclo[5,4,0]-7-undecene was slowly added dropwise and the mixture was stirred at 40° to 45° C. for 1 hour. After removal of the solvent, the residue was dissolved in dilute hydrochloric acid and extracted with chloroform. The chloroform layer separated out was washed with water, dried and evaporated in vacuo to obtain 2.3 g of ethyl 5,8-dihydro-5-ethyl-8-oxofuro[3,2-b]-1,8-naphthyridine-7-carboxylate.

Provenance & Evidence