Acetoacetic Acid → 2,6-Dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid

Participants

Reaction Steps

A mixture of 22.2 g of bornyl ester of acetoacetic acid 7 g of hexamethylenetetramine, 3.9 g of ammonium acetate and 150 ml of ethyl alcohol is refluxed for 30 minutes. After cooling a yellow substance is precipitated which is then filtered-off and recrystallized from ethanol. There are obtained 12 g (52% of the theoretical value) of bornyl ester of 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid as a yellow crystalline substance having melting point of 171°-173° C.

Provenance & Evidence