HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → (1,4-dimethyl-1H-imidazol-2-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 1,4-Dimethylimidazole | HCID 138733 | — |
| Reactant | (5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-3-yl)methanol | HCID 12923422 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Product | (1,4-dimethyl-1H-imidazol-2-yl)methanol | HCID 12923402 | — |
Reaction Steps
The reaction of 1,4-dimethylimidazole (5.65 g.) with n-butyl lithium followed by treatment with formaldehyde according to the method described for the preparation of 3-hydroxymethyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine (used for Example 224) gave 1,4-dimethyl-2-hydroxymethylimidazole (2.71 g.), m.p. 125°-126° (ethyl acetate-petroleum ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04293697 |
| Source dataset | uspto-grants-1981_10 |
| ORD ID | ord-a8f3257180fe45f08899f52cfa231997 |
| Source note | uspto-grants-1981_10 |