反应详情

温度

80 °C

Sunitinib methanesulfonate (1.0 g) and H2O (60 mL) was added into a flask in r.t. and heated to 80° C., the mixture turned clear. The pH of the mixture was adjusted to 8˜9 with 1N NaOH and cooled r.t., was stirred overnight, filtered, washed, and dried in vacuo to give 0.65 g of crude sunitinib with 99.2% purity by HPLC analysis in 99.5% yield.

1. temperaturecooled r.t.
2. filtrationfiltered
3. washwashed
4. customdried in vacuo