N-3-Bromopropylphthalimide → 3-(3-Aminopropylamino)-1,2,4-thiadiazole

HRID 847910Notes

Reaction equation

HRID 847910 reaction equation
[NH2:1][C:2]1[N:6]=[CH:5][S:4][N:3]=1.C1(=O)[N:11](CCCBr)[C:10](=O)[C:9]2=CC=CC=[C:8]12>>[NH2:11][CH2:10][CH2:9][CH2:8][NH:1][C:2]1[N:6]=[CH:5][S:4][N:3]=1

Participants

3

Reactant 2

HCID 21611N-3-BromopropylphthalimideHCID 202496641,2,4-Thiadiazol-3-amine

Product 1

HCID 205576553-(3-Aminopropylamino)-1,2,4-thiadiazole

Procedure

Reaction of 3-amino-1,2,4-thiadiazole with 3-phthalimidopropyl bromide and hydrazinolysis of the product gives 3-(3-aminopropylamino)-1,2,4-thiadiazole and from this intermediate N-methyl-N'-[3-(3-(1,2,4-thiadiazolyl)-amino)propyl]thiourea is prepared.

Sources & evidence

ORD record
ord-8fb7b8240d6e4f8b96cd0fae49433a1f
Source dataset
uspto-grants-1981_10
Patent number
US04293697

Reaction notes

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