HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → N-Cyano-N'-methyl-N"-[2-(2-(2-pyrimidyl)ethyl)thioethyl]guanidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-Cyano-2,3-dimethylisothiourea | HCID 111103 | — |
| Reactant | 2-(2-Chloroethyl)pyrimidine | HCID 20567500 | — |
| Reactant | 2-[2-(2-Aminoethyl)thioethyl]pyrimidine | HCID 20567719 | — |
| Reactant | 2-(Pyrimidin-2-yl)ethan-1-ol | HCID 22493585 | — |
| Product | N-Cyano-N'-methyl-N"-[2-(2-(2-pyrimidyl)ethyl)thioethyl]guanidine | HCID 178485017 | — |
Reaction Steps
By the procedure of Example 17 using 2-(2-chloroethyl)pyrimidine, prepared by treating 2-(2-hydroxyethyl)pyrimidine with thionyl chloride, as the starting material, 2-[2-(2-aminoethyl)thioethyl]pyrimidine is prepared, which when treated with N-cyano-N', S-dimethylisothiourea by the procedure of Example 3(a) gives the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04293699 |
| Source dataset | uspto-grants-1981_10 |
| ORD ID | ord-9f149f6039304089a57870ab97ee770f |
| Source note | uspto-grants-1981_10 |