HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → Methyl 1-5-(4-methylbenzoyl)pyrrole-2-acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 5-[cyanohydroxy(4-methylphenyl)methyl]-1-methylpyrrole-2-acetate | HCID 12940095 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | Methyl 1-5-(4-methylbenzoyl)pyrrole-2-acetate | HCID 13041412 | 93.6% |
Reaction Steps
Methyl 5-[cyanohydroxy(4-methylphenyl)methyl]-1-methylpyrrole-2-acetate (0.161 g, 0.540 mmoles) was dissolved in 30 ml of ether and shaken with 10 percent NaOH, washed with brine and dried over MgSO4. Evaporation of the ether yielded 0.130 g (86.1 percent) of methyl 1-5-(4-methylbenzoyl)pyrrole-2-acetate, mp 118°-120°. The IR was identical to an authentic sample of methyl 1-methyl-5-(4-methylbenzoyl)pyrrole-2-acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04294760 |
| Source dataset | uspto-grants-1981_10 |
| ORD ID | ord-ade4c04787d34bea92389e1d6f82d20b |
| Source note | uspto-grants-1981_10 |