Permethric acid → Cypermethrin

Participants

Reaction Steps

A slurry of 38 g of 2-oxo-2-(3-phenoxy-α-cyanobenzyloxy)-5,5-dimethyl-1,3,2-dioxa-phosphorinane, 26 g of the sodium salt of 3-(2,2-dichloro-vinyl)-2,2-dimethylcyclopropane-1-carboxylic acid and 260 g of diglycol dimethyl ether was heated to 150° C. for 20 hours, while stirring. After cooling, the mixture was poured into water and the product was extracted with ligroin. The ligroin phase was washed 3 times with water and dried over sodium sulphate. After filtration, the ligroin was distilled off from the filtrate in vacuo and the residue was subjected to incipient distillation under a high vacuum. 32 g (77% of theory) of 3-(2,2-dichlorovinyl)-2,2-dimethyl-cyclopropane-1-carboxylic acid 3-phenoxy-α-cyano-benzyl ester were obtained as the residue.

Provenance & Evidence