Ammonia → HCID 12899589, compound

HRID 848091Notes

Reaction equation

HRID 848091 reaction equation
Cl[C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[CH2:11][S:12][CH2:13][CH3:14].[NH3:15]>O>[CH2:13]([S:12][CH2:11][N:6]1[CH:5]=[N:4][C:3]2[C:7]1=[N:8][CH:9]=[N:10][C:2]=2[NH2:15])[CH3:14]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 12899588HCID 12899588, compound

Product 1

HCID 12899589HCID 12899589, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

6-Chloro-9-ethylthiomethylpurine (1.5 g) and liquid ammonia (20 ml) were placed in a bomb and heated at 60° C. overnight. Evaporation of the ammonia gave a residue which was treated with cold water, filtered, and washed with cold water. This yielded 9-ethylthiomethyladenine (1.17 g) as a white solid, m.p. 140°-142° C. Recrystallization from ethanol gave white plates, m.p. 142°-143° C.

Workup

  1. customEvaporation of the ammonia
  2. customgave a residue which
  3. filtrationfiltered
  4. washwashed with cold water
  5. customRecrystallization from ethanol
  6. customgave white plates, m.p. 142°-143° C.

Sources & evidence

ORD record
ord-15ff792be10e4364bee42f60efe274e9
Source dataset
uspto-grants-1981_10
Patent number
US04294831

Reaction notes

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