Methyl [[(methoxycarbonyl)amino](methylthio)methylene]carbamate → HCID 135951922, compound

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Reaction Steps

Three and one-half (3.5) grams (g) of the dihydrochloride salt of β-amino-β-(2,6-dichlorophenyl)ethylamine is added to a suitable reaction vessel containing 30 milliliters (ml) of saturated sodium bicarbonate. The resulting mixture is stirred, diluted with 50 mls of isopropanol and a solution of 2.8 g of a mixture of 1-mono- amd 1,3-bis(methoxycarbonyl)-S-methylisothiourea in 50 ml of chloroform is added. Stirring is continued for six days and the solvents are removed under vacuum. The residue is stirred with 70 ml of 2% hydrochloric acid for 30 minutes and the acidic aqueous solution is washed several times with ether, once with toluene and is then treated with excess of saturated sodium bicarbonate. The resulting precipitate is collected by filtration, stirred with water, collected again and dried at 55° under vacuum affording 2.25 g of 4,5-dihydro-4-(2,6-dichlorophenyl)-2-methoxycarbonylaminoimidazole, melting point (mp) 227°-229° C. A small sample is further purified by recrystallization from toluene to give 4,5-dihydro-4-(2,6-dichlorophenyl)-2-methoxycarbonylaminoimidazole, mp 230°-231° C.

Provenance & Evidence