HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorobenzothiazole → Methyl α-(2-benzothiazolylthio)benzeneacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorobenzothiazole | HCID 11987 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Bromo-1,3-benzothiazole | HCID 612040 | — |
| Reactant | HCID 12900987 | HCID 12900987 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl α-(2-benzothiazolylthio)benzeneacetate | HCID 54106029 | — |
Reaction Steps
18.2 g of 2-mercapto-2-phenylacetic acid methyl ester is added to a suspension of 2.4 g of NaH in 200 ml of DMF and the mixture is stirred until the evolution of gas has ceased. 17 g of 2-chlorobenzothiazole (or 21.5 g of 2-bromobenzothiazole) is then introduced. The mixture is stirred for 5 hours at 80° and is worked up in the customary manner to give 2-(benzothiazol-2-ylthio)-2-phenylacetic acid methyl ester, in the form of an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04294839 |
| Source dataset | uspto-grants-1981_10 |
| ORD ID | ord-75d9164de36b4c3fa3658f3996a3c7f7 |
| Source note | uspto-grants-1981_10 |