Potassium thiocyanate → HCID 20566324, compound

Participants

Reaction Steps

Sodium nitrite (1.38 g, 0.02 mol) in water (15 ml) was added dropwise to a solution of 3-(4-aminophenylthiomethyl)-1,2,4-oxadiazole, (4.14 g, 0.02 mol) in acetic acid (120 ml) and 2 N sulphuric acid (40 ml) at 0° with stirring. The pale yellow solution thus obtained was added over 30 min. to a stirred mixture of cuprous thiocyanate (6 g) and potassium thiocyanate (60 g) in water (100 ml) at 0°, and the mixture stirred overnight. The mixture was then neutralised with solid sodium hydrogen carbonate and extracted with chloroform to give a yellow solid which was recrystallised from propan-2-ol to give 3-(4-thiocyanatophenylthiomethyl)-1,2,4-oxadiazole, m.p. 78°.

Provenance & Evidence