HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-Benzyl (1-amino-1-oxo-3-phenylpropan-2-yl)carbamate → (2R)-2-amino-3-phenylpropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-Benzyl (1-amino-1-oxo-3-phenylpropan-2-yl)carbamate | HCID 68077307 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (2R)-2-amino-3-phenylpropanamide | HCID 7000171 | 98.4% |
Reaction Steps
A mixture of (R)-benzyl 1-amino-1-oxo-3-phenylpropan-2-ylcarbamate (910 mg, 3.05 mmol) and Pd—C (10%, 200 mg) in MeOH (20 mL) was hydrogenated under balloon H2 for 16 h. It was filtered through celite. The filtrate was concentrated in vacuo to give D-phenylalanine amide as a white solid (493 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846928B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-3a46015da6164ff6a39edee6f71e7158 |
| Source note | uspto-grants-2014_09 |