HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorobenzene → 1-(4-Chlorophenyl) 3-(1-benzoyl 4-piperidyl) 1-propanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorobenzene | HCID 7964 | — |
| Reactant | 3-(1-Benzoylpiperidin-4-yl)propanoic acid | HCID 19108454 | — |
| Solvent | Carbon Disulfide | HCID 6348 | — |
| Product | 1-(4-Chlorophenyl) 3-(1-benzoyl 4-piperidyl) 1-propanone | HCID 54426774 | 187.6% |
Reaction Steps
The procedure is as in Example 1, starting from 18 g of chlorobenzene instead of 9.9 g of anisol, 350 ml of carbon disulfide instead of 157 ml and 35 g instead of 15.7 g of 3-(1-benzoyl 4-piperidyl) propionic acid. 40.1 g of crude 1-(4-chlorophenyl) 3-(1-benzoyl 4-piperidyl) 1-propanone are obtained in the form of an oil which crystallizes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04294841 |
| Source dataset | uspto-grants-1981_10 |
| ORD ID | ord-012a3a87a68944188cc83cb3e4fbdb56 |
| Source note | uspto-grants-1981_10 |