Phenacylamine → HCID 54521924, compound

Participants

Reaction Steps

The procedure is as in Example 13 starting from 4 g of 2-aminoacetophenone and 6.42 g of pyridine-4-carbaldehyde in 14 ml of methanol. 5.2 g of a 50/50 mixture of 1-(2-aminophenyl) 3-(4-pyridyl) 3-hydroxy 1-propanone and of 1-(2-aminophenyl) 3-(4-pyridyl) 2-propene-1-one are obtained. The constituents of this mixture are separated by chromatography on a silica column (eluant: mixture of 80 parts by volume of ethyl acetate and 20 parts by volume of cyclohexane). 2.3 g of 1-(2-aminophenyl) 3-(4-pyridyl) 2-propene-1-one, melting at 168° C. are obtained.

Provenance & Evidence