Acetic Anhydride → HCID 53824685, compound

Participants

Reaction Conditions

Reaction Steps

45 g of 1-(2-aminophenyl) 3-(4-pyridyl) 2-propene-1-one (product of Example 14) are contacted with 13.5 ml of acetic anhydride. After 10 minutes at 100° C., the solution obtained is cooled, diluted with 80 ml of water, then the pH is slowly adjusted to 6 (while maintaining the temperature at 5° C.) by the addition of a concentrated solution of sodium hydroxide. After stirring for one hour, the precipitate formed is filtered, washed with water, then dried at 80° C. under vacuum. 53 g of 1-(2-acetylaminophenyl) 3-(4-pyridyl) 2-propene-1-one which melts at 130° C. are obtained.

Provenance & Evidence