Fumaric Acid → HCID 3061539, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 10.2 g of 1-(4-methoxyphenyl) 3-(4-piperidyl) 1-propanone in 130 ml of dry tetrahydrofurane, maintained at 5° C. and under a nitrogen atmosphere, 2.8 g of lithium aluminum hydride are added in small portions. When the addition is complete, the reaction mixture is heated to 60° C. over five hours, then cooled to 0° C. Then, while maintaining this temperature, 25.2 ml of water are added very slowly. The mineral products are filtered and washed twice with 50 ml of hot methylenechloride. The collected organic solutions are concentrated by evaporation of the solvent. The oil obtained is dissolved in 150 ml of isopropanol and treated with 7.4 g of fumaric acid. In this manner, 7.8 g of 1-(4-methoxyphenyl) 3-(4-piperidyl) 1-propanol in the form of its fumarate are obtained.

Provenance & Evidence