Hexane → HCID 20566377, compound

HRID 848176Notes

Reaction equation

HRID 848176 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8][CH2:9][C:10]1[N:14]=[CH:13][O:12][N:11]=1.CCCCCC.C(O[CH:24](OCC)[C:25]1[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[C:27]([O:33][CH3:34])[CH:26]=1)C>>[CH3:34][O:33][C:27]1[CH:26]=[C:25]([CH:30]=[CH:29][C:28]=1[O:31][CH3:32])[CH:24]=[N:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8][CH2:9][C:10]1[N:14]=[CH:13][O:12][N:11]=1

Participants

4

Reactant 3

HCID 8058HexaneHCID 2278854-(diethoxymethyl)-1,2-dimethoxybenzeneHCID 3057622Benzenamine, 2-((1,2,4-oxadiazol-3-ylmethyl)thio)-

Product 1

HCID 20566377HCID 20566377, compound

Procedure

A solution of 3-(2-aminophenylthiomethyl)1,2,4-oxadiazole (4.2 g) in 3,4-dimethoxybenzaldehyde diethyl acetal (9.6 g) was heated under reflux for 30 minutes. On cooling and the addition of hexane yellow crystals precipitated. These were removed by filtration and re-crystallised from ethanol to give 3-[2-(3,4-dimethoxybenzylideneamino)phenylthiomethyl]-1,2,4-oxadiazole, m.p. 146°.

Workup

  1. temperatureunder reflux for 30 minutes
  2. temperatureOn cooling
  3. customprecipitated
  4. customThese were removed by filtration
  5. customre-crystallised from ethanol

Sources & evidence

ORD record
ord-25e670b0ba274e4f93794ae23ec8da01
Source dataset
uspto-grants-1981_10
Patent number
US04294843

Reaction notes

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