HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-Isopropoxyimino-2-(2-aminothiazol-4-yl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 2-(2-amino-4-thiazolyl)-2-(1-methylethoxyimino)acetate | HCID 54000557 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Isopropoxyimino-2-(2-aminothiazol-4-yl)acetic acid | HCID 54100055 | 64.1% |
Reaction Steps
Ethyl 2-(2-aminothiazol-4-yl)-2-iso-propoxyiminoacetate (syn isomer, 26.8 g.), 1N aqueous solution of sodium hydroxide (156 ml.), methanol (156 ml.) and tetrahydrofuran (100 ml.) were treated in a similar manner to that of Example D-(4) to give 2-(2-aminothiazol-4-yl)-2-iso-propoxyiminoacetic acid (syn isomer, 15.3 g.), mp. 151° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04294960 |
| Source dataset | uspto-grants-1981_10 |
| ORD ID | ord-354c63498a3445f0928dda8be7e34716 |
| Source note | uspto-grants-1981_10 |