HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-(2-Aminothiazol-4-yl)-2-cyclohexyloxyiminoacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 2-(2-aminothiazol-4-yl)-2-cyclohexyloxyiminoacetate | HCID 53692631 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(2-Aminothiazol-4-yl)-2-cyclohexyloxyiminoacetic acid | HCID 54507597 | 66.2% |
Reaction Steps
Ethyl 2-(2-aminothiazol-4-yl)-2-cyclohexyloxyiminoacetate (syn isomer, 3.5 g.), 2 N aqueous solution of sodium hydroxide (11.8 ml.), methanol (11.8 ml.) and tetrahydrofuran (11.8 ml.) were treated in a similar manner to that of Example F-(4) to give 2-(2-aminothiazol-4-yl)-2-cyclohexyloxyiminoacetic acid (syn isomer, 2.1 g.), mp. 148° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04294960 |
| Source dataset | uspto-grants-1981_10 |
| ORD ID | ord-e8017a4a4481461e9973ebe93866ef76 |
| Source note | uspto-grants-1981_10 |