HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 131712509, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | (6R)-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | HCID 12941984 | — |
| Reactant | HCID 54077075 | HCID 54077075 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 131712509 | HCID 131712509 | 71% |
Reaction Steps
A solution of 2-(2-formamidothiazol-4-yl)-2-cyclopentyloxyiminoacetic acid (syn isomer, 1.5 g.), phosphoryl chloride (974 mg.), N,N-dimethylformamide (464 mg.) and tetrahydrofuran (15 ml.) and a solution of 7-amino-3-cephem-4-carboxylic acid (1.38 g.) in 50% aqueous acetone (14 ml.) were treated in a similar manner to that of Example 15-(1) to give 7-[2-(2-formamidothiazol-4-yl)-2-cyclopentyloxyiminoacetamido]-3-cephem-4-carboxylic acid (syn isomer, 1.75 g.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04294960 |
| Source dataset | uspto-grants-1981_10 |
| ORD ID | ord-908157d5f4814009a76a9e3e5f0a1bb8 |
| Source note | uspto-grants-1981_10 |