Succinic Acid → 1,4-Bis[2-(2-hydroxyethylamino)ethylamino]-5,8-dihydroxyanthraquinone disuccinate salt

HRID 848419Notes

Reaction equation

HRID 848419 reaction equation
[OH:1][CH2:2][CH2:3][NH:4][CH2:5][CH2:6][NH:7][C:8]1[C:21]2[C:20](=[O:22])[C:19]3[C:14](=[C:15]([OH:24])[CH:16]=[CH:17][C:18]=3[OH:23])[C:13](=[O:25])[C:12]=2[C:11]([NH:26][CH2:27][CH2:28][NH:29][CH2:30][CH2:31][OH:32])=[CH:10][CH:9]=1.[C:33]([OH:40])(=[O:39])[CH2:34][CH2:35][C:36]([OH:38])=[O:37]>C(O)C>[C:33]([OH:40])(=[O:39])[CH2:34][CH2:35][C:36]([OH:38])=[O:37].[C:33]([OH:40])(=[O:39])[CH2:34][CH2:35][C:36]([OH:38])=[O:37].[OH:1][CH2:2][CH2:3][NH:4][CH2:5][CH2:6][NH:7][C:8]1[C:21]2[C:20](=[O:22])[C:19]3[C:14](=[C:15]([OH:24])[CH:16]=[CH:17][C:18]=3[OH:23])[C:13](=[O:25])[C:12]=2[C:11]([NH:26][CH2:27][CH2:28][NH:29][CH2:30][CH2:31][OH:32])=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 1110Succinic AcidHCID 4212Mitoxantrone

Product 1

HCID 867369151,4-Bis[2-(2-hydroxyethylamino)ethylamino]-5,8-dihydroxyanthraquinone disuccinate salt

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 222 mg. of 1,4-bis[2-(2-hydroxyethylamino)ethylamino]-5,8-dihydroxyanthraquinone, 118 mg. of succinic acid, and 50 ml. of ethanol is heated under reflux for 30 minutes to give the title compound.

Workup

  1. additionA mixture of 222 mg
  2. temperatureunder reflux for 30 minutes

Sources & evidence

ORD record
ord-ec0cc3a8d0de4aa8b8354903c7954143
Source dataset
uspto-grants-1981_10
Patent number
US04296030

Reaction notes

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