Malic Acid → 1,4-Bis[2-(3-hydroxypropylamino)ethylamino)-5,8-dihydroxyanthraquinone dimalate salt

HRID 848420Notes

Reaction equation

HRID 848420 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][NH:5][CH2:6][CH2:7][NH:8][C:9]1[C:22]2[C:21](=[O:23])[C:20]3[C:15](=[C:16]([OH:25])[CH:17]=[CH:18][C:19]=3[OH:24])[C:14](=[O:26])[C:13]=2[C:12]([NH:27][CH2:28][CH2:29][NH:30][CH2:31][CH2:32][CH2:33][OH:34])=[CH:11][CH:10]=1.[C:35]([OH:43])(=[O:42])[CH:36]([CH2:38][C:39]([OH:41])=[O:40])[OH:37]>C(O)C>[C:35]([OH:43])(=[O:42])[CH:36]([CH2:38][C:39]([OH:41])=[O:40])[OH:37].[C:35]([OH:43])(=[O:42])[CH:36]([CH2:38][C:39]([OH:41])=[O:40])[OH:37].[OH:1][CH2:2][CH2:3][CH2:4][NH:5][CH2:6][CH2:7][NH:8][C:9]1[C:22]2[C:21](=[O:23])[C:20]3[C:15](=[C:16]([OH:25])[CH:17]=[CH:18][C:19]=3[OH:24])[C:14](=[O:26])[C:13]=2[C:12]([NH:27][CH2:28][CH2:29][NH:30][CH2:31][CH2:32][CH2:33][OH:34])=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 525Malic AcidHCID 1531601,4-Bis[2-(3-hydroxypropylamino)ethylamino]-5,8-dihydroxyanthraquinone

Product 1

HCID 1317117371,4-Bis[2-(3-hydroxypropylamino)ethylamino)-5,8-dihydroxyanthraquinone dimalate salt

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 228 mg. of 1,4-bis[2-(3-hydroxypropylamino)ethylamino]-5,8-dihydroxyanthraquinone, 134 mg. of DL-malic acid, and 50 ml. of ethanol is heated under reflux for 30 minutes to give the title compound.

Workup

  1. additionA mixture of 228 mg
  2. temperatureunder reflux for 30 minutes

Sources & evidence

ORD record
ord-fcb2e2b789d04f1c8a4797f9a2e0559c
Source dataset
uspto-grants-1981_10
Patent number
US04296030

Reaction notes

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