HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 84845Generated: October 29, 2026
Hydrogen Peroxide → (R)-tert-butyl 1-(4-carbamoyl-3-(3-methylisothiazol-5-ylamino)phenylamino)-3-methoxypropan-2-ylcarbamate
https://huagongshe.com/reaction/84845
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrogen Peroxide | HCID 784 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 67773713 | HCID 67773713 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Water | HCID 962 | — |
| Product | (R)-tert-butyl 1-(4-carbamoyl-3-(3-methylisothiazol-5-ylamino)phenylamino)-3-methoxypropan-2-ylcarbamate | HCID 67515833 | — |
Reaction Steps
The above mentioned crude oil from step 2 was dissolved in DMSO (2 mL), K2CO3 (500 mg, 3.6 mmol) was added; then H2O2 (50% aq., 2 mL) was added dropwise (gas evolved). The mixture was stirred at 80° C. for 15 min, cooled and was diluted with water, the resulting precipitate was collected by filtration, dried in vacuo to give (R)-tert-butyl 1-(4-carbamoyl-3-(3-methylisothiazol-5-ylamino)phenylamino)-3-methoxypropan-2-ylcarbamate as solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08846928B2 |
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| Source dataset | uspto-grants-2014_09 |
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| ORD ID | ord-b0b9b8e2b2fb4c38b813825d5c2962f1 |
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| Source note | uspto-grants-2014_09 |
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