Ammonia → 1-(4-mercapto-1-oxobutyl)-4-oxo-L-proline

HRID 848453Notes

Reaction equation

C([S:4][CH2:5][CH2:6][CH2:7][C:8]([N:10]1[CH2:17][C:16](=[O:18])[CH2:15][C@H:11]1[C:12]([OH:14])=[O:13])=[O:9])(=O)C.N>>[SH:4][CH2:5][CH2:6][CH2:7][C:8]([N:10]1[CH2:17][C:16](=[O:18])[CH2:15][C@H:11]1[C:12]([OH:14])=[O:13])=[O:9]

Participants

Reactant 2

HCID 222Ammonia

HCID 543554581-[4-(acetylthio)-1-oxobutyl]-4-oxo-L-proline

Product 1

HCID 540878971-(4-mercapto-1-oxobutyl)-4-oxo-L-proline

Procedure

The product form part (a) is hydrolyzed with concentrated ammonia according to the procedure of Example 2 to yield 1-(4-mercapto-1-oxobutyl)-4-oxo-L-proline.

Sources & evidence

ORD record: ord-7bb675805da2423eaa42e2756bd18100
Source dataset: uspto-grants-1981_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04296113

Reaction notes

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