Ammonia → 1-(3-mercapto-1-oxopropyl)-4-oxo-L-proline, methyl ester

HRID 848463Notes

Reaction equation

HRID 848463 reaction equation
C([S:4][CH2:5][CH2:6][C:7]([N:9]1[CH2:17][C:16](=[O:18])[CH2:15][C@H:10]1[C:11]([O:13][CH3:14])=[O:12])=[O:8])(=O)C.N>>[SH:4][CH2:5][CH2:6][C:7]([N:9]1[CH2:17][C:16](=[O:18])[CH2:15][C@H:10]1[C:11]([O:13][CH3:14])=[O:12])=[O:8]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 127736751-[3-(acetylthio)-1-oxopropyl]-4-oxo-L-proline, methyl ester

Product 1

HCID 1317125111-(3-mercapto-1-oxopropyl)-4-oxo-L-proline, methyl ester

Procedure

The product from Example 28 is hydrolyzed with concentrated ammonia according to the procedure of Example 2 to yield 1-(3-mercapto-1-oxopropyl)-4-oxo-L-proline, methyl ester.

Sources & evidence

ORD record
ord-63d0e06d22774faeab0eed8cc108d411
Source dataset
uspto-grants-1981_10
Patent number
US04296113

Reaction notes

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