HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 1-(4-Chlorophenyl)-1,2-dihydro-3-methoxyquinoxalin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 3-Chloro-1-(4-chlorophenyl)-1,2-dihydroquinoxalin-2-one | HCID 20565466 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(4-Chlorophenyl)-1,2-dihydro-3-methoxyquinoxalin-2-one | HCID 20565470 | 67.3% |
Reaction Steps
A solution of 3-chloro-1-(4-chlorophenyl)-1,2-dihydroquinoxalin-2-one (7.7 g) and sodium methoxide (2.0 g) in methanol (70 ml) was refluxed for 4 hours. Water was added and the product was extracted into chloroform. Evaporation of the solvent followed by crystallization from ethanol gave the title compound (5.1 g) mp 245°-247° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04296114 |
| Source dataset | uspto-grants-1981_10 |
| ORD ID | ord-5bc0ee4b730f4650a315b20d8aa00db9 |
| Source note | uspto-grants-1981_10 |