HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 848477Generated: October 30, 2026
Water → 1-(4-Chlorophenyl)-3-cyano-1,2-dihydroquinoxalin-2-one
https://huagongshe.com/reaction/848477
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | 3-Chloro-1-(4-chlorophenyl)-1,2-dihydroquinoxalin-2-one | HCID 20565466 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(4-Chlorophenyl)-3-cyano-1,2-dihydroquinoxalin-2-one | HCID 20565490 | 65.1% |
Reaction Steps
A mixture of 3-chloro-1-(4-chlorophenyl)-1,2-dihydroquinoxalin-2-one (10.0 g) and potassium cyanide (2.5 g) in dry dimethylformamide (100 ml) was heated at 140° C. for 24 hours. The mixture was added to water and the product was extracted into chloroform. Evaporation of the solvent and crystallisation of the residue from ethanol gave the title compound (6.3 g) mp 232°-235° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04296114 |
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| Source dataset | uspto-grants-1981_10 |
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| ORD ID | ord-943ac14bea574d5d86eabdb074bc7e10 |
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| Source note | uspto-grants-1981_10 |
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