Water → 4-(4-Chlorophenyl)-3,4-dihydro-3-oxo-2-quinoxaline carboxamide

HRID 848478Notes

Reaction equation

HRID 848478 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=[C:10]([C:18]#[N:19])[C:9]2=[O:20])=[CH:4][CH:3]=1.[OH2:21]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=[C:10]([C:18]([NH2:19])=[O:21])[C:9]2=[O:20])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 962WaterHCID 205654901-(4-Chlorophenyl)-3-cyano-1,2-dihydroquinoxalin-2-one

Product 1

HCID 205654494-(4-Chlorophenyl)-3,4-dihydro-3-oxo-2-quinoxaline carboxamide

Procedure

1-(4-Chlorophenyl)-3-cyano-1,2-dihydroquinoxalin-2-one (6.6 g) was heated at 110° C. for 1 hour with polyphosphoric acid (25 g). The mixture was diluted with water and extracted with chloroform. Evaporation of the solvent and recrystallisation of the residue from ethanol gave the title compound (3.8 g) mp 293°-297° (decomp).

Workup

  1. extractionextracted with chloroform
  2. customEvaporation of the solvent and recrystallisation of the residue from ethanol

Sources & evidence

ORD record
ord-a39fe64c827c4a35832fc728b2595452
Source dataset
uspto-grants-1981_10
Patent number
US04296114

Reaction notes

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