HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (R)-2-amino-3-methoxypropanamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (R)-tert-butyl 1-amino-3-methoxy-1-oxopropan-2-ylcarbamate | HCID 86666155 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (R)-2-amino-3-methoxypropanamide hydrochloride | HCID 86666156 | — |
Reaction Steps
A solution of (R)-tert-butyl 1-amino-3-methoxy-1-oxopropan-2-ylcarbamate (342 mg, 1.57 mmol) in 4N HCl in dioxane (5 mL) was stirred at room temperature for 18 h. It was then concentrated in vacuo to give (R)-2-amino-3-methoxypropanamide hydrochloride (260 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846928B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-111f4a4fd8d44694bb449d1b508e299a |
| Source note | uspto-grants-2014_09 |