Acetic Anhydride → HCID 12874834, compound

HRID 848517Notes

Reaction equation

HRID 848517 reaction equation
[C:1](OC(=O)C)(=[O:3])[CH3:2].[CH3:8][N:9]([CH3:27])[CH2:10][CH2:11][CH:12]([O:19][C:20]1[CH:25]=[CH:24][C:23]([NH2:26])=[CH:22][CH:21]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[OH-].[Na+]>C1C=CC=CC=1>[CH3:27][N:9]([CH3:8])[CH2:10][CH2:11][CH:12]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[O:19][C:20]1[CH:25]=[CH:24][C:23]([NH:26][C:1](=[O:3])[CH3:2])=[CH:22][CH:21]=1

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 14798Sodium HydroxideHCID 12874833HCID 12874833, compound

Product 1

HCID 12874834HCID 12874834, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

2.8 ml of 98% acetic acid anhydride were added under an inert atmosphere to a solution of 7.6 g of N,N-dimethyl-γ-(4-amino-phenoxy)-benzene-propanamine in 80 ml of benzene and the mixture was stirred for 45 minutes. 50 ml of 2 N sodium hydroxide were added thereto and the decanted organic phase was washed with aqueous sodium chloride solution and was dried, treated with activated carbon and filtered. The filtrate was evaporated to dryness to obtain 9 g of N-[4-(3-dimethylamino-1-phenyl-propyloxy)-phenyl]acetamide.

Workup

  1. washthe decanted organic phase was washed with aqueous sodium chloride solution
  2. customwas dried
  3. additiontreated with activated carbon
  4. filtrationfiltered
  5. customThe filtrate was evaporated to dryness

Sources & evidence

ORD record
ord-1fca68c93d4e4bb3b720bc61f81769d9
Source dataset
uspto-grants-1981_10
Patent number
US04296126

Reaction notes

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