1,4-Dihydroxy-2-naphthoic acid → 1-Hydroxy-4-(beta,gamma-dibromopropyloxy)-2-naphthoic acid

Participants

Reaction Conditions

Reaction Steps

60 g (0.3 mol) of 1,4-dihydroxy-2-naphthoic acid was added to 150 ml of 2,3-dibromopropanol and, under heating at 90° C. with stirring, hydrogen chloride gas was bubbled in the mixture during a reaction period of 2 hours. The mixture was cooled to 10° to 20° C. and the crystals precipitated were collected by filteration to obtain 42.4 g (35% yield) of 1-hydroxy-4-(β,γ-dibromopropyloxy)-2-naphthoic acid.

Provenance & Evidence