Isopropylamine → N-isopropyl-2,3-dimethyl-2-(1-methylpropyl)valeramide

Participants

Reaction Steps

2-sec-butyl-2,3-dimethylpentanoyl chloride (bp. 108°-110°/17 mm) was prepared in the usual way from 2-sec-butyl-2,3-dimethylpentanoic acid and thionyl chloride. A solution of this acid chloride (2.0 g) in ether (30 ml) was added with stirring to a solution of isopropylamine (2.0 g) in ether (100 ml). After 16 hours the external solution was washed with dilute hydrochloric acid and water, dried (MgSO4), and concentrated to give a white solid. This solid was recrystallized from petroleum ether (bp. 40°-60°) to give N-isopropyl-2-sec-butyl-2,3-dimethylpentanamide, MP. 74°-6°.

Provenance & Evidence