HCID 12774888, compound → HCID 12780062, compound

HRID 848638Notes

Reaction equation

HRID 848638 reaction equation
[CH3:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([O:8][CH2:9][N:10]2[C:15](=[O:16])[NH:14][C:13](=[O:17])[CH:12]=[N:11]2)=[O:7])=[CH:4][CH:3]=1.[H][H]>C(O)C.[Pt]=O>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([O:8][CH2:9][N:10]2[C:15](=[O:16])[NH:14][C:13](=[O:17])[CH2:12][NH:11]2)=[O:7])=[CH:18][CH:19]=1

Participants

5

Reactant 2

HCID 12774888HCID 12774888, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 12780062HCID 12780062, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

2-(4-Methylbenzoyloxymethyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine (2.1 g) is dissolved in ethanol (100 ml), and the mixture is added with platinum oxide (400 mg) and stirred at room temperature for 3 hours in an atmosphere of hydrogen. After the completion of the reaction, the catalyst is filtered off, and the filtrate is concentrated in vacuo to give a pale yellow liquid. The liquid is purified by chromatography over silica gel using a mixture of chloroform/methanol as an eluent to give white crystals of 2-(4-methylbenzoyloxymethyl)-3,5-dioxo-hexahydro-1,2,4-triazine (Compound No. 73). The product is recrystallized from a mixture of ethanol/n-hexane. Yield, 1.35 g (62.2%). M.P., 163.5° C.

Workup

  1. customAfter the completion of the reaction
  2. filtrationthe catalyst is filtered off
  3. concentrationthe filtrate is concentrated in vacuo
  4. customto give a pale yellow liquid
  5. customThe liquid is purified by chromatography over silica gel using
  6. additiona mixture of chloroform/methanol as an eluent

Sources & evidence

ORD record
ord-82644de6d4084cabb189557016c6b8c5
Source dataset
uspto-grants-1981_10
Patent number
US04297129

Reaction notes

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