Water → HCID 86735827, compound

HRID 848664Notes

Reaction equation

HRID 848664 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:14]([O:16]C)=[O:15])[C:5]([CH2:11][O:12][CH3:13])=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].O>[OH-].[Na+]>[Cl:1][C:2]1[CH:3]=[C:4]([C:14]([OH:16])=[O:15])[C:5]([CH2:11][O:12][CH3:13])=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9]

Participants

4

Reactant 2

HCID 962WaterHCID 86735826HCID 86735826, compound

Product 1

HCID 86735827HCID 86735827, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A slurry of methyl 4-chloro-α-methoxy-5-nitro-o-toluate (7.0 g.) in dilute sodium hydroxide (35 ml of IN) is stirred about 30 hours. The yellow slurry is then diluted with 50 ml. of water resulting in a clear yellow solution. The solution is extracted with ether, then the aqueous layer is separated and acidified to give 5.7 g. of an off-white solid. A sample recrystallized from benzene has a mp 155°-157°.

Workup

  1. additionThe yellow slurry is then diluted with 50 ml
  2. extractionThe solution is extracted with ether
  3. customthe aqueous layer is separated
  4. customto give 5.7 g
  5. customA sample recrystallized from benzene

Sources & evidence

ORD record
ord-428bf00081024dbbb88fce75b69ddb56
Source dataset
uspto-grants-1981_10
Patent number
US04297127

Reaction notes

Loading…