Dimethyl Sulfate → HCID 13014497, compound

HRID 848705Notes

Reaction equation

HRID 848705 reaction equation
[C:1]([C:3]1[C:4](=[O:18])[NH:5][C:6](=[O:17])[N:7]([C:9]2[C:14]([CH3:15])=[CH:13][CH:12]=[CH:11][C:10]=2[CH3:16])[CH:8]=1)#[N:2].S(OC)(O[CH3:23])(=O)=O>[OH-].[Na+]>[C:1]([C:3]1[C:4](=[O:18])[N:5]([CH3:23])[C:6](=[O:17])[N:7]([C:9]2[C:14]([CH3:15])=[CH:13][CH:12]=[CH:11][C:10]=2[CH3:16])[CH:8]=1)#[N:2]

Participants

4

Reactant 2

HCID 6497Dimethyl SulfateHCID 13014421HCID 13014421, compound

Product 1

HCID 13014497HCID 13014497, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

To a mixture of 5-cyano-1-(2,6-dimethylphenyl)uracil (0.1 mol) and 80 ml of five percent sodium hydroxide solution, with stirring, is slowly added dimethyl sulfate (0.1 mol). The reaction mixture is stirred for about 2 hours and then filtered, washed with water and dried to yield 5-cyano-1-(2,6-dimethylphenyl)-3-methyluracil, m.p. 198.2°-199.5°.

Workup

  1. stirringThe reaction mixture is stirred for about 2 hours
  2. filtrationfiltered
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-ee416237c73b47f1bed088a9973a89a8
Source dataset
uspto-grants-1981_10
Patent number
US04297297

Reaction notes

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